Article
Association of cumulative allelic losses with tumor aggressiveness in hepatocellular carcinoma.
Journal of hepatology - 1 Oct 1997
Tamura S, Nakamori S, Kuroki T, Sasaki Y, Furukawa H, Ishikawa O, Imaoka S, Nakamura Y
Abstract excerpt
BACKGROUND/AIMS: Loss of heterozygosity on various chromosomal arms has been reported in hepatocellular carcinoma and a multistep accumulation of genetic alteration has become accepted as the mechanism underlying progression of the disease. Although cumulative genetic alterations may imply more m...
Topics
- Adult
- Aged
- Alleles
- Carcinoma, Hepatocellular
- Disease Progression
- Disease-Free Survival
- Female
- Humans
- Liver Neoplasms
- Loss of Heterozygosity
- Male
- Microsatellite Repeats
- Middle Aged
- Multivariate Analysis