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Article

Association of cumulative allelic losses with tumor aggressiveness in hepatocellular carcinoma.

Journal of hepatology - 1 Oct 1997

Tamura S, Nakamori S, Kuroki T, Sasaki Y, Furukawa H, Ishikawa O, Imaoka S, Nakamura Y

Abstract excerpt

BACKGROUND/AIMS: Loss of heterozygosity on various chromosomal arms has been reported in hepatocellular carcinoma and a multistep accumulation of genetic alteration has become accepted as the mechanism underlying progression of the disease. Although cumulative genetic alterations may imply more malignant tumors with poorer prognosis, the assumption requires further investigation. METHODS: Presence of loss of...

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PMID: 9365043
DOI: 10.1016/s0168-8278(97)80084-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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