Allelotype and loss of heterozygosity of p53 in primary and recurrent hepatocellular carcinomas. A study of 150 patients.

doi:10.1002/1097-0142(19940101)73:1<42::aid-cncr2820730109>3.0.co;2-d

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Article

Allelotype and loss of heterozygosity of p53 in primary and recurrent hepatocellular carcinomas. A study of 150 patients.

Cancer - 1 Jan 1994

Hsu H C, Peng S Y, Lai P L, Sheu J C, Chen D S, Lin L I, Slagle B L, Butel J S

Abstract excerpt

BACKGROUND: The allelotype and loss of heterozygosity (LOH) of the p53 gene in human hepatocellular carcinoma (HCC) were studied in 150 patients with resected primary HCC and 18 with recurrent HCC. METHODS: DNA samples of paired HCC and livers were cut with BanII enzyme for the study of p53 allelotype and allele loss. The medical records of the patients were carefully reviewed. RESULTS: Sixty-four (42.7%)...

Topics

Adult
Aged
Alleles
Carcinoma, Hepatocellular
Chromosome Mapping
Diabetes Complications
Female
Gene Deletion
Genes, p53
Genotype
Hepatitis B Surface Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatitis B e Antigens

Hepatitis C

Heterozygote

Humans

Liver Neoplasms

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 7506118
DOI: 10.1002/1097-0142(19940101)73:1<42::aid-cncr2820730109>3.0.co;2-d

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7506118-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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