Article
Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans.
Current biology : CB - 19 Nov 2002
Piano Fabio, Schetter Aaron J, Morton Diane G, Gunsalus Kristin C, Reinke Valerie, Kim Stuart K, Kemphues Kenneth J
Abstract excerpt
Recently, a set of 766 genes that are enriched in the ovary as compared to the soma was identified by microarray analysis [1]. Here, we report a functional analysis of 98% of these genes by RNA interference (RNAi). Over half the genes tested showed at least one detectable phenotype, most commonly embryonic lethality, consistent with the expectation that ovary transcripts would be enriched for genes that are...
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