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Article

Genomic Identification and Functional Characterization of Essential Genes in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 2 Mar 2018

Qin Zhaozhao, Johnsen Robert, Yu Shicheng, Chu Jeffrey Shih-Chieh, Baillie David L, Chen Nansheng

Abstract excerpt

Using combined genetic mapping, Illumina sequencing, bioinformatics analyses, and experimental validation, we identified 60 essential genes from 104 lethal mutations in two genomic regions of Caenorhabditis elegans totaling ∼14 Mb on chromosome III(mid) and chromosome V(left). Five of the 60 genes had not previously been shown to have lethal phenotypes by RNA interference depletion. By analyzing the regions...

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Identifiers

PMID: 29339407
DOI: 10.1534/g3.117.300338
PMCID: PMC5844317

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Source receipt: pubmed, retrieved 7 Sept 2026.

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