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Article

Identification of essential genes in Caenorhabditis elegans through whole-genome sequencing of legacy mutant collections.

G3 (Bethesda, Md.) - 8 Dec 2021

Li-Leger Erica, Feichtinger Richard, Flibotte Stephane, Holzkamp Heinke, Schnabel Ralf, Moerman Donald G

Abstract excerpt

It has been estimated that 15%-30% of the ∼20,000 genes in C. elegans are essential, yet many of these genes remain to be identified or characterized. With the goal of identifying unknown essential genes, we performed whole-genome sequencing on complementation pairs from legacy collections of maternal-effect lethal and sterile mutants. This approach uncovered maternal genes required for embryonic development and...

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PMID: 34550348
DOI: 10.1093/g3journal/jkab328
PMCID: PMC8664450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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