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Article

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.

Nature - 16 Jan 2003

Kamath Ravi S, Fraser Andrew G, Dong Yan, Poulin Gino, Durbin Richard, Gotta Monica, Kanapin Alexander, Le Bot Nathalie, Moreno Sergio, Sohrmann Marc, Welchman David P, Zipperlen Peder, Ahringer Julie

Abstract excerpt

A principal challenge currently facing biologists is how to connect the complete DNA sequence of an organism to its development and behaviour. Large-scale targeted-deletions have been successful in defining gene functions in the single-celled yeast Saccharomyces cerevisiae, but comparable analyses have yet to be performed in an animal. Here we describe the use of RNA interference to inhibit the function of...

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PMID: 12529635
DOI: 10.1038/nature01278

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