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Article

Systematic analysis of pleiotropy in C. elegans early embryogenesis.

PLoS computational biology - 29 Feb 2008

Zou Lihua, Sriswasdi Sira, Ross Brian, Missiuro Patrycja V, Liu Jun, Ge Hui

Abstract excerpt

Pleiotropy refers to the phenomenon in which a single gene controls several distinct, and seemingly unrelated, phenotypic effects. We use C. elegans early embryogenesis as a model to conduct systematic studies of pleiotropy. We analyze high-throughput RNA interference (RNAi) data from C. elegans and identify "phenotypic signatures", which are sets of cellular defects indicative of certain biological functions. By...

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PMID: 18463698
DOI: 10.1371/journal.pcbi.1000003
PMCID: PMC2265476

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