Article
Systematic analysis of pleiotropy in C. elegans early embryogenesis.
PLoS computational biology - 29 Feb 2008
Zou Lihua, Sriswasdi Sira, Ross Brian, Missiuro Patrycja V, Liu Jun, Ge Hui
Abstract excerpt
Pleiotropy refers to the phenomenon in which a single gene controls several distinct, and seemingly unrelated, phenotypic effects. We use C. elegans early embryogenesis as a model to conduct systematic studies of pleiotropy. We analyze high-throughput RNA interference (RNAi) data from C. elegans and identify "phenotypic signatures", which are sets of cellular defects indicative of certain biological functions. By...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Cycle
- Cell Cycle Proteins
- Computer Simulation
- Embryonic Development
- Evolution, Molecular
- Gene Expression Profiling
- Models, Biological
- Mutation