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Article

Histologic-genetic mapping by allele-specific PCR reveals intraurothelial spread of p53 mutant tumor clones.

Laboratory investigation; a journal of technical methods and pathology - 1 Nov 2002

Stoehr Robert, Knuechel Ruth, Boecker Joerg, Blaszyk Hagen, Schmitt Ruediger, Filbeck Thomas, Hofstaedter Ferdinand, Hartmann Arndt

Abstract excerpt

Common and clinically important features of urothelial carcinomas are multifocality and a high rate of recurrence. Molecular studies demonstrated that multifocal tumors are frequently composed of one tumor clone spreading throughout the urothelial tract. A combination of histologic and genetic mapping of cystectomy specimens from bladder cancer patients is a valuable tool to study bladder carcinogenesis and tumor...

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PMID: 12429815
DOI: 10.1097/01.lab.0000035022.29742.85

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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