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Article

Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies

25 Jul 2002

Abstract excerpt

Multifocal occurrence and frequent recurrence are characteristic features of urothelial carcinomas of both the urinary bladder and the upper urinary tract. To describe the clonal nature of these tumors, 2 theories have been proposed. The monoclonality hypothesis describes the multiple tumors as descendants of a single genetically transformed cell spreading throughout the urothelium. In contrast, field...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 12209580
DOI: 10.1002/ijc.10544

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