Article
Identification of p53 gene mutations in bladder cancers and urine samples.
Science (New York, N.Y.) - 3 May 1991
Sidransky D, Von Eschenbach A, Tsai Y C, Jones P, Summerhayes I, Marshall F, Paul M, Green P, Hamilton S R, Frost P
Abstract excerpt
Although bladder cancers are very common, little is known about their molecular pathogenesis. In this study, invasive bladder cancers were evaluated for the presence of gene mutations in the p53 suppressor gene. Of 18 tumors evaluated, 11 (61 percent) were found to have genetic alterations of p53...
Topics
- Alleles
- Base Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Urinary Bladder Neoplasms
- Urine