Article
Clinical significance of allelotype profiling for urothelial carcinoma.
Urology - 1 Aug 2003
Tzai Tzong-Shin, Chen Helen Hai-Wen, Chan Shih-Huang, Ho Chung-Liang, Tsai Yuh-Shyan, Cheng Hong-Lin, Dai Yuan-Chang, Lin Johnny Shinn-Nan, Yang Wen-Hong, Chow Nan-Haw
Abstract excerpt
OBJECTIVES: To perform a global loss of heterozygosity (LOH) analysis on a cohort of urothelial carcinoma to investigate the clinical implication of specific chromosomal loss. Allelic deletions detected as LOH have been used to study the markers for carcinogenesis. METHODS: We examined the allelic loss on 14 chromosomal regions in a total of 71 cases of urothelial carcinoma. The results were analyzed in relation...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Carcinoma, Transitional Cell
- Chromosome Deletion
- Chromosome Mapping
- Cohort Studies
- Female
- Gene Expression Profiling
- Genotype
- Humans
- Kidney Neoplasms
- Loss of Heterozygosity