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Article

Origin of multifocal carcinomas of the bladder and upper urinary tract: Molecular analysis and clinical implications

1 Aug 2005

Abstract excerpt

The simultaneous or metachronous development of multifocal tumors with identical or variable histological features in the urothelial tract in a single patient is a well-known characteristic of urothelial cancer. To explain this phenomenon, two distinct concepts have been proposed: the 'field defect' hypothesis according to which urothelial cells in patients are primed to undergo transformation by previous...

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PMID: 16174043
DOI: 10.1111/j.1442-2042.2005.01155.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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