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Article

Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract.

Oncogene - 9 Aug 2001

Hafner C, Knuechel R, Zanardo L, Dietmaier W, Blaszyk H, Cheville J, Hofstaedter F, Hartmann A

Abstract excerpt

Multifocality and recurrence of urothelial carcinoma may result from either the field effect of carcinogens leading to oligoclonal tumors or monoclonal tumor spread. Previous molecular studies, favoring the monoclonality hypothesis, are mostly limited to the urinary bladder. We investigated genetic alterations in a total of 94 synchronous or metachronous multifocal tumors from 19 patients with at least one tumor...

Read the complete abstract on PubMed

Topics

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Share to Chromosomes, Human, Pair 9
Share to MLH1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MSH2 gene

Share to Genes, p53

Share to Loss of Heterozygosity

Share to Microsatellite Repeats

Share to Mutation

Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 11521204
DOI: 10.1038/sj.onc.1204671

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract.PMID 11521204Read ↗

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