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Article

No association between schizophrenia and polymorphisms in COMT in two large samples.

The American journal of psychiatry - 1 Sept 2005

Williams Hywel J, Glaser Beate, Williams Nigel M, Norton Nadine, Zammit Stanley, MacGregor Stuart, Kirov George K, Owen Michael J, O'Donovan Michael C

Abstract excerpt

OBJECTIVE: A valine/methionine polymorphism in the catechol O-methyltransferase (COMT) gene has been proposed to influence susceptibility to schizophrenia, as has a COMT haplotype in Ashkenazi Jewish and Irish subjects. The authors examined these hypotheses. METHOD: They reviewed data from more than 2,800 individuals, including almost 1,200 with schizophrenia, from case-control and family-based European...

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Source

Identifiers

PMID: 16135635
DOI: 10.1176/appi.ajp.162.9.1736

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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No association between schizophrenia and polymorphisms in COMT in two large samples.PMID 16135635Read ↗

No association of catechol-O-methyltransferase polymorphisms with schizophrenia in the Han Chinese population.Semantic proximity Read ↗

Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.Semantic proximity Read ↗

The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample.Semantic proximity Read ↗

A highly significant association between a COMT haplotype and schizophrenia.Semantic proximity Read ↗

Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis.Semantic proximity Read ↗

Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies.Semantic proximity Read ↗

Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.Semantic proximity Read ↗

Association study of catechol-O-methyltransferase gene polymorphisms with schizophrenia and psychopathological symptoms in Han Chinese.Semantic proximity Read ↗

No evidence for linkage between COMT and schizophrenia in a French population.Semantic proximity Read ↗

Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.Semantic proximity Read ↗

No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.Semantic proximity Read ↗

Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families.Semantic proximity Read ↗

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