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Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment.

Pharmacogenomics - 1 Mar 2009

Gupta Meenal, Bhatnagar Pallav, Grover Sandeep, Kaur Harpreet, Baghel Ruchi, Bhasin Yasha, Chauhan Chitra, Verma Binuja, Manduva Vallikiran, Mukherjee Odity, Purushottam Meera, Sharma Abhay, Jain Sanjeev, Brahmachari Samir K, Kukreti Ritushree

Abstract excerpt

AIM: We investigated the catechol-O-methyltrasferase (COMT) gene, which is a strong functional and positional candidate gene for schizophrenia and therapeutic response to antipsychotic medication. MATERIALS & METHODS: Single-locus as well as detailed haplotype-based association analysis of the COMT gene with schizophrenia and antipsychotic treatment response was carried out using seven COMT polymorphisms in 398...

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Antipsychotic Agents
Catechol O-Methyltransferase
Cognition Disorders
DiGeorge Syndrome

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Reference Values

Sequence Deletion

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PMID: 19290789
DOI: 10.2217/14622416.10.3.385

Genes

COMT

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