Article
Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families.
Molecular psychiatry - 1 Oct 2004
Chen X, Wang X, O'Neill A F, Walsh D, Kendler K S
Abstract excerpt
The enzyme catechol-o-methyltransferase (COMT) transfers a methyl group from adenosylmethionine to catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. This methylation results in the degradation of catecholamines. The involvement of the COMT gene in the metabolic pathway of these neurotransmitters has made it an attractive candidate gene for many psychiatric disorders. In this...
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