Article
Association of the 3' region of COMT with schizophrenia in Taiwan.
Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Apr 2009
Chien Yi-Ling, Liu Chih-Min, Fann Cathy Shen-Jang, Liu Yu-Li, Hwu Hai-Gwo
Abstract excerpt
BACKGROUND/PURPOSE: The Val108/158Met (rs4680) single nucleotide polymorphism (SNP) in the catechol-O-methyltransferase (COMT) gene contributes to genetic susceptibility to schizophrenia, which is specifically related to impairments in executive functioning. A different genomic region composed of three SNPs (rs737865, rs4680, rs165599) within the COMT gene has been reported to be significantly associated with...
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