Article
Multiple roles for cAMP-dependent protein kinase during Dictyostelium development.
Developmental biology - 1 Jan 1992
Harwood A J, Hopper N A, Simon M N, Bouzid S, Veron M, Williams J G
Abstract excerpt
The cAMP-dependent protein kinase (PKA) holoenzyme of Dictyostelium comprises a single regulatory (R) and catalytic (C) subunit, and both proteins increase in concentration during cellular aggregation. In order to determine the role of the kinase, we have constructed mutants of the R subunit that are defective in cAMP binding, in inhibition of the C subunit, or in both functions. Analysis of these mutants...
Topics
- Animals
- Base Sequence
- Dictyostelium
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Molecular Sequence Data
- Mutation
- Protein Kinase Inhibitors
- Protein Kinases