Article
Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium.
Journal of cell science - 1 May 2017
Scavello Margarethakay, Petlick Alexandra R, Ramesh Ramya, Thompson Valery F, Lotfi Pouya, Charest Pascale G
Abstract excerpt
Efficient directed migration requires tight regulation of chemoattractant signal transduction pathways in both space and time, but the mechanisms involved in such regulation are not well understood. Here, we investigated the role of protein kinase A (PKA) in controlling signaling of the chemoattractant cAMP in Dictyostelium discoideum We found that cells lacking PKA display severe chemotaxis defects, including...
Topics
- Actins
- Chemotactic Factors
- Chemotaxis
- Cyclic AMP-Dependent Protein Kinases
- Dictyostelium
- Mechanistic Target of Rapamycin Complex 2
- Models, Biological
- Myosins
- Phenotype
- Protozoan Proteins
- Signal Transduction
- Time Factors
- rap1 GTP-Binding Proteins