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Article

Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium.

Journal of cell science - 1 May 2017

Scavello Margarethakay, Petlick Alexandra R, Ramesh Ramya, Thompson Valery F, Lotfi Pouya, Charest Pascale G

Abstract excerpt

Efficient directed migration requires tight regulation of chemoattractant signal transduction pathways in both space and time, but the mechanisms involved in such regulation are not well understood. Here, we investigated the role of protein kinase A (PKA) in controlling signaling of the chemoattractant cAMP in Dictyostelium discoideum We found that cells lacking PKA display severe chemotaxis defects, including...

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Identifiers

PMID: 28302905
DOI: 10.1242/jcs.177170
PMCID: PMC5450229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium.PMID 28302905Read ↗

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