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Article

Activated Galpha subunits can inhibit multiple signal transduction pathways during Dictyostelium development.

Developmental biology - 15 Nov 1999

Srinivasan J, Gundersen R E, Hadwiger J A

Abstract excerpt

Mutations impairing the GTPase activity of G protein Galpha subunits can result in activated Galpha subunits that affect signal transduction and cellular responses and, in some cases, promote tumor formation. An analogous mutation in the Dictyostelium Galpha4 subunit gene (Q200L substitution) was constructed and found to inhibit Galpha4-mediated responses to folic acid, including the accumulation of cyclic...

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Identifiers

PMID: 10545250
DOI: 10.1006/dbio.1999.9474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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