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Article

Multimerization of the ligand binding domains of cyclic nucleotide-gated channels.

Neuron - 26 Sept 2002

Matulef Kimberly, Zagotta William N

Abstract excerpt

Cyclic nucleotide-gated (CNG) channels comprise four subunits and are activated by the direct binding of cyclic nucleotide to an intracellular domain on each subunit. This ligand binding domain is thought to contain a beta roll followed by two alpha helices, designated the B and C helices. To examine the quaternary structure of CNG channels and how it changes during ion channel gating, we introduced single...

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Identifiers

PMID: 12367509
DOI: 10.1016/s0896-6273(02)00878-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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