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Article

C-terminal movement during gating in cyclic nucleotide-modulated channels.

The Journal of biological chemistry - 23 May 2008

Craven Kimberley B, Olivier Nelson B, Zagotta William N

Abstract excerpt

Activation of cyclic nucleotide-modulated channels such as CNG and HCN channels is promoted by ligand-induced conformational changes in their C-terminal regions. The primary intersubunit interface of these C termini includes two salt bridges per subunit, formed between three residues (one positiv...

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Source

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Identifiers

PMID: 18367452
DOI: 10.1074/jbc.M710463200
PMCID: PMC2386932

Genes

CNGA1
HCN2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18367452-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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