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Article

Molecular rearrangements in the ligand-binding domain of cyclic nucleotide-gated channels.

Neuron - 1 Oct 1999

Matulef K, Flynn G E, Zagotta W N

Abstract excerpt

Cyclic nucleotide-gated (CNG) channels are activated in response to the direct binding of cyclic nucleotides to an intracellular domain. This domain is thought to contain a beta roll and two alpha helices, designated the B and C helices. To probe the conformational changes occurring in the ligand-binding domain during channel activation, we used the substituted cysteine accessibility method (SCAM). We found that...

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PMID: 10571237
DOI: 10.1016/s0896-6273(00)80857-0

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