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Article

Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel.

The Journal of biological chemistry - 9 Mar 2018

Shobair Mahmoud, Popov Konstantin I, Dang Yan L, He Hong, Stutts M Jackson, Dokholyan Nikolay V

Abstract excerpt

The epithelial sodium channel (ENaC) mediates sodium absorption in lung, kidney, and colon epithelia. Channels in the ENaC/degenerin family possess an extracellular region that senses physicochemical changes in the extracellular milieu and allosterically regulates the channel opening. Proteolytic cleavage activates the ENaC opening, by the removal of specific segments in the finger domains of the α- and γ...

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Identifiers

PMID: 29358325
DOI: 10.1074/jbc.RA117.000604
PMCID: PMC5846138

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