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Article

Functional interactions between A' helices in the C-linker of open CNG channels.

The Journal of general physiology - 1 Mar 2005

Hua Li, Gordon Sharona E

Abstract excerpt

Cyclic nucleotide-gated (CNG) channels are nonselective cation channels that are activated by the direct binding of the cyclic nucleotides cAMP and cGMP. The region linking the last membrane-spanning region (S6) to the cyclic nucleotide binding domain in the COOH terminus, termed the C-linker, has been shown to play an important role in coupling cyclic nucleotide binding to opening of the pore. In this study, we...

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Identifiers

PMID: 15738051
DOI: 10.1085/jgp.200409187
PMCID: PMC1282461

Genes

CNGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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