Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The gating mechanism in cyclic nucleotide-gated ion channels.

Scientific reports - 8 Jan 2018

Mazzolini Monica, Arcangeletti Manuel, Marchesi Arin, Napolitano Luisa M R, Grosa Debora, Maity Sourav, Anselmi Claudio, Torre Vincent

Abstract excerpt

Cyclic nucleotide-gated (CNG) channels mediate transduction in several sensory neurons. These channels use the free energy of CNs' binding to open the pore, a process referred to as gating. CNG channels belong to the superfamily of voltage-gated channels, where the motion of the α-helix S6 controls gating in most of its members. To date, only the open, cGMP-bound, structure of a CNG channel has been determined at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic Nucleotide-Gated Cation Channels

Share to Ion Channel Gating

Share to Position-Specific Scoring Matrices

Share to Protein Conformation

Share to Protein Folding

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 29311674
DOI: 10.1038/s41598-017-18499-0
PMCID: PMC5758780

Genes

CNGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The gating mechanism in cyclic nucleotide-gated ion channels.PMID 29311674Read ↗

Gating in CNGA1 channels.Semantic proximity Read ↗

Mutations reveal voltage gating of CNGA1 channels in saturating cGMP.Semantic proximity Read ↗

C-terminal movement during gating in cyclic nucleotide-modulated channels.Semantic proximity Read ↗

Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.Semantic proximity Read ↗

Fifty years of gating currents and channel gating.Semantic proximity Read ↗

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.Semantic proximity Read ↗

Gating of the MlotiK1 potassium channel involves large rearrangements of the cyclic nucleotide-binding domains.Semantic proximity Read ↗

Conformational rearrangements in the S6 domain and C-linker during gating in CNGA1 channels.Semantic proximity Read ↗

The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.Semantic proximity Read ↗

Gating Pore Currents in Sodium Channels.Semantic proximity Read ↗

Rotational movement during cyclic nucleotide-gated channel opening.Semantic proximity Read ↗

An Allosteric Model for Electromechanical Coupling in Cardiac CNBD ChannelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.