Article
Gating of the MlotiK1 potassium channel involves large rearrangements of the cyclic nucleotide-binding domains.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2011
Mari Stefania A, Pessoa João, Altieri Stephen, Hensen Ulf, Thomas Lise, Morais-Cabral João H, Müller Daniel J
Abstract excerpt
Cyclic nucleotide-regulated ion channels are present in bacteria, plants, vertebrates, and humans. In higher organisms, they are closely involved in signaling networks of vision and olfaction. Binding of cAMP or cGMP favors the activation of these ion channels. Despite a wealth of structural and studies, there is a lack of structural data describing the gating process in a full-length cyclic nucleotide-regulated...
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