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Article

Cysteine residues in the nucleotide binding domains regulate the conductance state of CFTR channels.

Biophysical journal - 1 Mar 2002

Harrington Melissa A, Kopito Ron R

Abstract excerpt

Gating of cystic fibrosis transmembrane conductance regulator (CFTR) channels requires intermolecular or interdomain interactions, but the exact nature and physiological significance of those interactions remains uncertain. Subconductance states of the channel may result from alterations in interactions among domains, and studying mutant channels enriched for a single conductance type may elucidate those...

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Identifiers

PMID: 11867445
DOI: 10.1016/S0006-3495(02)75484-2
PMCID: PMC1301931

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cysteine residues in the nucleotide binding domains regulate the conductance state of CFTR channels.PMID 11867445Read ↗

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