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Article

Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains.

Pharmacology, biochemistry, and behavior - 1 Nov 2002

Kest Benjamin, Hopkins Eileen, Palmese Christina A, Adler Michael, Mogil Jeffrey S

Abstract excerpt

The present study assessed the analgesic potency of morphine in 11 inbred mouse strains before and after chronic morphine treatment. Using the 49 degrees C tail-withdrawal test, significant strain differences in morphine AD(50) estimates derived from cumulative dose-response curves were noted prior to tolerance induction on Day 1. AD(50) estimates were reassessed on Day 4, after three daily systemic morphine...

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Source

Identifiers

PMID: 12213527
DOI: 10.1016/s0091-3057(02)00908-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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