Article
A survey of acute and chronic heroin dependence in ten inbred mouse strains: evidence of genetic correlation with morphine dependence.
Pharmacology, biochemistry, and behavior - 1 Sept 2008
Klein Gad, Juni Aaron, Waxman Amanda R, Arout Caroline A, Inturrisi Charles E, Kest Benjamin
Abstract excerpt
Heroin and morphine exposure can cause physical dependence, with symptoms manifesting during their withdrawal. Inter-individual differences in symptom frequency during morphine withdrawal are a common finding that, in rodents, is demonstrably attributable to genotype. However, it is not known whether inter-individual differences characterize heroin withdrawal, and whether such variation can be similarly...
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