Morphine analgesia in male inbred genetic diversity mice recapitulates the among-individual variance in response to morphine in humans.

doi:10.1002/ame2.12234

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Article

Morphine analgesia in male inbred genetic diversity mice recapitulates the among-individual variance in response to morphine in humans.

Animal models and experimental medicine - 1 Sept 2022

Yang Yin, Guan Bowen, Wei Qiang, Wang Wei, Meng Aimin

Abstract excerpt

Morphine is a widely used analgesic, but its use in clinical precision medicine is limited by the variance in response among individuals. Although previous studies have shown that individual differences in morphine can be explained in terms of pharmacodynamics and pharmacokinetics, genetic polymorphisms also play an important role. However, the genetic basis of different sensitivity and tolerance susceptibility...

Topics

Analgesia
Animals
Genetic Variation
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Morphine
Pain

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PMID: 35656737
DOI: 10.1002/ame2.12234
PMCID: PMC9240740

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