Article
Association of morphine-induced antinociception with variations in the 5' flanking and 3' untranslated regions of the mu opioid receptor gene in 10 inbred mouse strains.
Pharmacogenetics and genomics - 1 Nov 2008
Shigeta Yoshihiro, Kasai Shinya, Han Wenhua, Hata Harumi, Nishi Akinori, Takamatsu Yukio, Hagino Yoko, Yamamoto Hideko, Koide Tsuyoshi, Shiroishi Toshihiko, Kasai Kiyoto, Tsunashima Koichi, Kato Nobumasa, Ikeda Kazutaka
Abstract excerpt
OBJECTIVE: Genetic factors are hypothesized to be involved in interindividual differences in opioid sensitivity. Inbred mouse strains that are genetically different and isogenic within each strain are useful for elucidating the genetic mechanisms underlying the interindividual differences in opioid-induced analgesia. METHODS: We examined the effects of morphine in 10 inbred mouse strains, including wild-derived...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.