One or two genetic loci mediate high opiate analgesia in selectively bred mice.

doi:10.1016/0304-3959(94)00098-Y

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

One or two genetic loci mediate high opiate analgesia in selectively bred mice.

Pain - 1 Feb 1995

Mogil Jeffrey S, Marek Przemyslaw, Flodman Pamela, Spence Anne M, Sternberg Wendy F, Kest Benjamin, Sadowski Bogdan, Liebeskind John C

Abstract excerpt

The analgesic responses of humans and laboratory animals are characterized by substantial individual differences. The genetic basis of this variability can be studied experimentally in rodents using a program of selective breeding. One such program selected for high (HA) and low (LA) swim stress-induced analgesia (SSIA) on the hot-plate (56 degrees C) test in Swiss-Webster mice. These lines, which have been...

Topics

3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
Analgesia
Analgesics
Animals
Chromosome Mapping
Crosses, Genetic
Female
Genes, Dominant
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Morphine

Phenotype

Pyrrolidines

Receptors, Opioid, kappa

Selection, Genetic

Stress, Physiological

Source

Open in PubMed

Identifiers

PMID: 7784097
DOI: 10.1016/0304-3959(94)00098-Y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7784097-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

One or two genetic loci mediate high opiate analgesia in selectively bred mice.PMID 7784097Read ↗

Sex and genotype determine the selective activation of neurochemically-distinct mechanisms of swim stress-induced analgesia.Semantic proximity Read ↗

Oligogenic determination of morphine analgesic magnitude: a genetic analysis of selectively bred mouse lines.Semantic proximity Read ↗

A polymorphism in exon 2 of the delta-opioid receptor affects nociception in response to specific agonists and antagonists in mice selectively bred for high and low analgesia.Semantic proximity Read ↗

Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.Semantic proximity Read ↗

The genetic mediation of individual differences in sensitivity to pain and its inhibitionSemantic proximity Read ↗

Pain, analgesia and genetics.Semantic proximity Read ↗

Chronic pain and genetic background interact and influence opioid analgesia, tolerance, and physical dependence.Semantic proximity Read ↗

The heritability of oxycodone reward and concomitant phenotypes in a LG/J × SM/J mouse advanced intercross line.Semantic proximity Read ↗

Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains.Semantic proximity Read ↗

Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia.Semantic proximity Read ↗

Aggression modulates genetic influences on morphine analgesia as assessed using a classical mendelian cross analysis.Semantic proximity Read ↗

The μ opiate receptor as a candidate gene for pain: Polymorphisms, variations in expression, nociception, and opiate responsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.