Article
Analgesic treatment with buprenorphine should be adapted to the mouse strain.
Pharmacology, biochemistry, and behavior - 1 Apr 2020
Rudeck Juliane, Vogl Silvia, Heinl Céline, Steinfath Matthias, Fritzwanker Sebastian, Kliewer Andrea, Schulz Stefan, Schönfelder Gilbert, Bert Bettina
Abstract excerpt
Buprenorphine is a commonly used opioid to treat moderate to severe pain in mice. Although strain differences regarding basal pain sensitivity and the analgesic effect of other opioids have been described for mice, the data for buprenorphine is incomplete. Hence, we investigated basal pain sensitivity and the analgesic effect of buprenorphine (0.42, 4.0 mg·kg-1) in male C57BL/6J, Balb/cJ and 129S1/SvImJ mice...
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