Article
Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes.
BMC genomics - 13 Jun 2006
Korostynski Michal, Kaminska-Chowaniec Dorota, Piechota Marcin, Przewlocki Ryszard
Abstract excerpt
BACKGROUND: Mouse strains with a contrasting response to morphine provide a unique model for studying the genetically determined diversity of sensitivity to opioid reward, tolerance and dependence. Four inbred strains selected for this study exhibit the most distinct opioid-related phenotypes. C57BL/6J and DBA/2J mice show remarkable differences in morphine-induced antinociception, self-administration and...
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