Article
Morphine tolerance in mice is independent of polymorphisms in opioid receptor sequences.
Brain research bulletin - 1 May 2001
Gant T M, Riba P, Lee N M
Abstract excerpt
Pharmacogenomics links individual drug response variation to genetic differences, such as single nucleotide polymorphisms (SNPs). In particular, pharmacogenomics will allow clinicians to use genetic diagnostics to predict the response of a patient to a drug. We investigated whether SNPs in opioid receptors correlated with the development of morphine tolerance in mouse strains that showed either high or low...
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