Chronic pain and genetic background interact and influence opioid analgesia, tolerance, and physical dependence.

Abstract excerpt

Opioids are commonly used in the treatment of moderate to severe pain. However, their chronic use is limited by analgesic tolerance and physical dependence. Few studies have examined how chronic pain affects the development of tolerance or dependence, and essentially no studies have looked at the role of both genetics and pain together. For these studies we used 12 strains of inbred mice. Groups of mice from each...

Topics

• Analgesics, Opioid
• Animals
• Chronic Disease
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Drug Tolerance
• Freund's Adjuvant
• Genetic Predisposition to Disease
• Genotype
• Inflammation Mediators