Article
Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains.
Nature genetics - 1 May 1994
Berrettini W H, Ferraro T N, Alexander R C, Buchberg A M, Vogel W H
Abstract excerpt
Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two-bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference...
Topics
- Animals
- Behavior, Addictive
- Chromosome Mapping
- Crosses, Genetic
- DNA, Satellite
- Drinking Behavior
- Female
- Genetic Predisposition to Disease
- Genotype
- Likelihood Functions
- Lod Score
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Morphine Dependence
- Phenotype
- Polymerase Chain Reaction