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Article

Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.

The Journal of pharmacology and experimental therapeutics - 1 Feb 1996

Mogil J S, Kest B, Sadowski B, Belknap J K

Abstract excerpt

Several genetic mouse models of opiate sensitivity have been identified or produced in an attempt to investigate mechanisms underlying individual variation in responses to opiate drugs like morphine. The major models in use presently are the DBA/2 (DBA) versus C57BL/6 (C57) inbred strains, the recombinantly inbred CXBK strain, and mouse lines selectively bred for high- and low-magnitude antinociception after swim...

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PMID: 8632319

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