Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.

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Article

Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.

The Journal of pharmacology and experimental therapeutics - 1 Feb 1996

Mogil J S, Kest B, Sadowski B, Belknap J K

Abstract excerpt

Several genetic mouse models of opiate sensitivity have been identified or produced in an attempt to investigate mechanisms underlying individual variation in responses to opiate drugs like morphine. The major models in use presently are the DBA/2 (DBA) versus C57BL/6 (C57) inbred strains, the re...

Topics

Analgesia
Analgesics, Opioid
Animals
Body Temperature
Dose-Response Relationship, Drug
Genotype
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Morphine
Motor Activity
Receptors, Opioid, kappa
Species Specificity
Spinal Cord

Source

Open in PubMed

Identifiers

PMID: 8632319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8632319-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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