Article
Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes.
Genomics - 1 Sept 2002
Powell Jason A, Gardner Alison E, Bais Anthony J, Hinze Susan J, Baker Elizabeth, Whitmore Scott, Crawford Joanna, Kochetkova Marina, Spendlove Hayley E, Doggett Norman A, Sutherland Grant R, Callen David F, Kremmidiotis Gabriel
Abstract excerpt
Loss of heterozygosity (LOH) of chromosome 16q24.3 is a common genetic alteration observed in invasive ductal and lobular breast carcinomas. We constructed a physical map and generated genomic DNA sequence data spanning 2.4 Mb in this region. Detailed in silico and in vitro analyses of the genomic sequence data enabled the identification of 104 genes. It was hypothesized that tumor-suppressor genes would exhibit...
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