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Article

Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing.

Genome biology - 1 Jan 2010

Zhao Qi, Kirkness Ewen F, Caballero Otavia L, Galante Pedro A, Parmigiani Raphael B, Edsall Lee, Kuan Samantha, Ye Zhen, Levy Samuel, Vasconcelos Ana Tereza R, Ren Bing, de Souza Sandro J, Camargo Anamaria A, Simpson Andrew J G, Strausberg Robert L

Abstract excerpt

BACKGROUND: To identify potential tumor suppressor genes, genome-wide data from exome and transcriptome sequencing were combined to search for genes with loss of heterozygosity and allele-specific expression. The analysis was conducted on the breast cancer cell line HCC1954, and a lymphoblast cell line from the same individual, HCC1954BL. RESULTS: By comparing exome sequences from the two cell lines, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Tumor Suppressor

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Share to High-Throughput Nucleotide Sequencing

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Source

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Identifiers

PMID: 21108794
DOI: 10.1186/gb-2010-11-11-r114
PMCID: PMC3156953

Genes

BRCA1
MSH3
SETX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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