Article
Allele loss on chromosome 16q24.2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread.
Cancer research - 15 Jan 1994
Tsuda H, Callen D F, Fukutomi T, Nakamura Y, Hirohashi S
Abstract excerpt
Loss of heterozygosity on chromosomal arm 16q has been shown to be a frequent event in sporadic breast cancer and is suggested to be involved in cancer development through inactivation of a tumor-suppressor gene. To specify the commonly deleted region in which the unknown tumor-suppressor gene is...
Topics
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 16
- Female
- Genes, Tumor Suppressor
- Genetic Markers
- Humans
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Phenotype
