Article
ATBF1 and NQO1 as candidate targets for allelic loss at chromosome arm 16q in breast cancer: absence of somatic ATBF1 mutations and no role for the C609T NQO1 polymorphism.
BMC cancer - 16 Apr 2008
Cleton-Jansen Anne-Marie, van Eijk Ronald, Lombaerts Marcel, Schmidt Marjanka K, Van't Veer Laura J, Philippo Katja, Zimmerman Rhyenne M E, Peterse Johannes L, Smit Vincent T B H M, van Wezel Tom, Cornelisse Cees J
Abstract excerpt
BACKGROUND: Loss of heterozygosity (LOH) at chromosome arm 16q is frequently observed in human breast cancer, suggesting that one or more target tumor suppressor genes (TSGs) are located there. However, detailed mapping of the smallest region of LOH has not yet resulted in the identification of a TSG at 16q. Therefore, the present study attempted to identify TSGs using an approach based on mRNA expression....
Topics
- Breast Neoplasms
- Chromosomes, Human, Pair 16
- DNA Mutational Analysis
- DNA, Neoplasm
- Down-Regulation
- Genes, Tumor Suppressor
- Homeodomain Proteins
- Humans
- Loss of Heterozygosity