Article
Loss, mutation and deregulation of L3MBTL4 in breast cancers.
Molecular cancer - 10 Aug 2010
Addou-Klouche Lynda, Adélaïde José, Finetti Pascal, Cervera Nathalie, Ferrari Anthony, Bekhouche Ismahane, Sircoulomb Fabrice, Sotiriou Christos, Viens Patrice, Moulessehoul Soraya, Bertucci François, Birnbaum Daniel, Chaffanet Max
Abstract excerpt
BACKGROUND: Many alterations are involved in mammary oncogenesis, including amplifications of oncogenes and losses of tumor suppressor genes (TSG). Losses may affect almost all chromosome arms and many TSGs remain to be identified. RESULTS: We studied 307 primary breast tumors and 47 breast cancer cell lines by high resolution array comparative genomic hybridization (aCGH). We identified a region on 18p11.31 lost...
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