Article
Identification of key regions and genes important in the pathogenesis of sezary syndrome by combining genomic and expression microarrays.
Cancer research - 1 Nov 2009
Caprini Elisabetta, Cristofoletti Cristina, Arcelli Diego, Fadda Paolo, Citterich Mauro Helmer, Sampogna Francesca, Magrelli Armando, Censi Federica, Torreri Paola, Frontani Marina, Scala Enrico, Picchio Maria Cristina, Temperani Paola, Monopoli Alessandro, Lombardo Giuseppe Alfonso, Taruscio Domenica, Narducci Maria Grazia, Russo Giandomenico
Abstract excerpt
In this study, we used single nucleotide polymorphism and comparative genomic hybridization array to study DNA copy number changes and loss of heterozygosity for 28 patients affected by Sézary syndrome (SS), a rare form of cutaneous T-cell lymphoma (CTCL). Our data identified, further confirming previous studies, recurrent losses of 17p13.2-p11.2 and 10p12.1-q26.3 occurring in 71% and 68% of cases, respectively;...
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