Article
Rapid and reliable method for cytochrome P450 2D6 genotyping.
Clinical chemistry - 1 Sept 2002
Stamer Ulrike M, Bayerer Bettina, Wolf Stephanie, Hoeft Andreas, Stüber Frank
Abstract excerpt
BACKGROUND: Single-nucleotide polymorphisms and single-base deletions within the cytochrome P450 2D6 (CYP2D6) gene have been associated with a poor metabolizer (PM) phenotype and display a frequency of 7-10% in the Caucasian population. METHODS: We developed a reliable and rapid procedure to identify five major PM-associated mutations (CYP2D6*4, *7, and *8) and deletions (CYP2D6*3 and *6) by real-time PCR with...
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