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Article

Alternative reliable method for cytochrome P450 2D6 poor metabolizers genotyping.

Molecular biotechnology - 1 Jan 2013

Pindurová E, Zourková A, Zrůstová J, Juřica J, Pavelka A

Abstract excerpt

High-resolution melting curve analysis (HRM) of polymerase chain reaction (PCR) amplicons has been described as a fast, cheap, and reliable closed-tube method of genotyping with no need for labeled primers or labeled probes. We adapted this melting analysis assay for the detection of the most common nonfunctional alleles of cytochrome P-450 (CYP) 2D6 in the Caucasian population that affect the metabolism of many...

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PMID: 22367691
DOI: 10.1007/s12033-012-9510-2

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