Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid and reliable genotyping procedure for detection of alleles with mutations, deletion, or/and duplication of the CYP2D6 gene.

Clinical biochemistry - 1 Aug 2009

Arneth Borros, Shams Mohammed, Hiemke Christoph, Härtter Sebastian

Abstract excerpt

BACKGROUND: Polymorphisms of cytochrome P450 2D6 (CYP2D6) have a significant effect on the pharmacokinetics of most tricyclic antidepressants. More than 150 alleles lead to four distinct phenotypes of drug metabolism. The phenotypes are described as ultrarapid, extensive, intermediate, and poor metabolizers. Therapeutic plasma levels of CYP2D6 substrates may be difficult to achieve. Here we describe a rapid and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents, Second-Generation
Share to Cyclohexanols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

Share to Depression

Share to Gene Duplication

Share to Sensitivity and Specificity

Share to Sequence Deletion

Share to Venlafaxine Hydrochloride

Source

Identifiers

PMID: 19393232
DOI: 10.1016/j.clinbiochem.2009.04.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid and reliable genotyping procedure for detection of alleles with mutations, deletion, or/and duplication of the CYP2D6 gene.PMID 19393232Read ↗

An observational study of Venlafaxine and CYP2D6 in clinical practice.Semantic proximity Read ↗

A new simple diagnostic assay for the identification of the major CYP2D6 genotypes by DNA sequencing analysis.Semantic proximity Read ↗

Cytochrome P450 2D6 genotype variation and venlafaxine dosage.Semantic proximity Read ↗

Rapid detection of common cytochrome P450 2D6 alleles in Caucasians.Semantic proximity Read ↗

CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine.Semantic proximity Read ↗

Rapid and reliable method for cytochrome P450 2D6 genotyping.Semantic proximity Read ↗

CYP2D6*11 and challenges in clinical genotyping of the highly polymorphic CYP2D6 gene.Semantic proximity Read ↗

Accurate determination of the CYP2D6 (*1/*4)xN genotype by quantitative PCR.Semantic proximity Read ↗

Complexities of CYP2D6 gene analysis and interpretation.Semantic proximity Read ↗

Identification of new alleles and the determination of alleles and genotypes frequencies at the CYP2D6 gene in Emiratis.Semantic proximity Read ↗

Serum concentrations of venlafaxine and its metabolites O-desmethylvenlafaxine and N-desmethylvenlafaxine in heterozygous carriers of the CYP2D6*3, *4 or *5 allele.Semantic proximity Read ↗

Venlafaxine metabolism as a marker of cytochrome P450 enzyme 2D6 metabolizer status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.