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Direct assessment of cytochrome P450 2D6 genotypes by high-resolution melting analysis and DNA sequencing.

Environmental toxicology and pharmacology - 1 Nov 2014

Chang Ya-Sian, Lee Chien-Chin, Liu Ting-Yuan, Chen Yu-Chia, Lu Hsiu-Chin, Chang Jan-Gowth

Abstract excerpt

We developed a CYP2D6 genotyping method that required only one polymerase chain reaction (PCR) followed by a high-resolution melting curve analysis (HRM) and DNA sequencing. DNA was extracted from peripheral blood samples obtained from 100 normal individuals. From the HRM analysis using three fragments of amplicons (exons 1, 6, and 9), we successfully identified four common CYP2D6 gene polymorphisms (100C>T,...

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PMID: 25461541
DOI: 10.1016/j.etap.2014.09.010

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