Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of CYP2B6 sequence variants by use of multiplex PCR with allele-specific genotyping.

Clinical chemistry - 1 Aug 2004

Jacob Robyn M, Johnstone Elaine C, Neville Matt J, Walton Robert T

Abstract excerpt

BACKGROUND: Cytochrome P450 2B6 (CYP2B6) has a role in the metabolism of many clinically important substances, but the variation within the CYP2B6 gene has not been fully characterized. The aim of the present study was to develop a reliable and robust assay for determining genotypic variants. METHODS: We used a two-stage procedure. An initial multiplex PCR reaction amplified the relevant gene fragments in exonic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP2B6

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Cytochrome P450 Family 2

Share to Gene Frequency

Share to Haplotypes

Share to Oxidoreductases, N-Demethylating

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 15178651
DOI: 10.1373/clinchem.2004.031708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of CYP2B6 sequence variants by use of multiplex PCR with allele-specific genotyping.PMID 15178651Read ↗

MALDI-TOF mass spectrometry for multiplex genotyping of CYP2B6 single-nucleotide polymorphisms.Semantic proximity Read ↗

A new simple diagnostic assay for the identification of the major CYP2D6 genotypes by DNA sequencing analysis.Semantic proximity Read ↗

Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance.Semantic proximity Read ↗

Allele and genotype frequencies of CYP2B6 in a Turkish population.Semantic proximity Read ↗

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevanceSemantic proximity Read ↗

Development and characterization of a rapid and comprehensive genotyping assay to detect the most common variants in cytochrome P450 2D6.Semantic proximity Read ↗

Rapid and reliable method for cytochrome P450 2D6 genotyping.Semantic proximity Read ↗

Cytochrome P450 2B6: function, genetics, and clinical relevanceSemantic proximity Read ↗

Detection of single nucleotide polymorphisms in CYP2B6 gene.Semantic proximity Read ↗

CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations—Implication for Drug Safety, Dosing, and Individualized TherapySemantic proximity Read ↗

CYP2B6 SINGLE NUCLEOTIDE POLYMORPHISMS IN AN AZERBAIJANI POPULATION.Semantic proximity Read ↗

Rapid detection of CYP2D6 null alleles by long distance- and multiplex-polymerase chain reaction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.